Great thread John! 
There is one application that has allowed me to keep my sanity and not be totally overwhelmed by the tasks necessary to perform my job. lol
If you are looking for a way to organize ALL of your business information in one place then Microsoft Office OneNote is the perfect software. I store things like, business contact info, media buys, link exchange, sponsor info./exclusives, staff tasks, payments, affiliate tags/banners for top programs, planned website structure to include SEO for each page.
You can import emails, paste information from any source on the internet and retain formating along with the URL to the source.