I think you’ll have a nice shot at some targeted traffic. The only thing that would concern me is that most fans of Pick’em video poker are probably a pretty savvy bunch, and they probably won’t be the wild slot-playing gamblers that are the most lucrative site visitors.
In land-based casinos, I hear that slot/VP manufacturer IGT is introducing Pick’em games to their lineup as well, with the name ‘Pick a Pair’. That might make for a higher profile for the game in the future. FYI, PickAPair.com is not available.
Your site will definitely fill a needed niche. Good luck!