Absolutely, with each major group that leaves the market becomes more and more valuable to anyone capable of successfully letting US players in. Multi billion dollar industries are never put out of business by mere laws. It will now turn into a lucrative fully illegal enterprise with all the attendant problems of international organised crime groups effectively taking over.
There will always be a market for US players, the question for US-facing affiliates now is do they mind working for gangsters?
More details here: